In the present study, a nanoapatite-mediated delivery system for imatinib has been proposed.\nNanohydroxyapatite (nHAp) was obtained by co-precipitation method, and its physicochemical\nproperties in combination with imatinib (IM) were studied by means of XRPD (X-ray Powder\nDiffraction), SEM-EDS (Scanning Electron Microscopy-Energy Dispersive X-ray Spectroscopy),\nFT-IR (Fourier-Transform Infrared Spectroscopy), absorption spectroscopy as well as DLS (Dynamic\nLight Scattering) techniques. The obtained hydroxyapatite was defined as nanosized rod-shaped\nparticles with high crystallinity. The amorphous imatinib was obtained by conversion of its crystalline\nform. The beneficial effects of amorphous pharmaceutical agents have been manifested in the\nhigher dissolution rate in body fluids improving their bioavailability. Imatinib-to-hydroxyapatite\ninteractions on the surface were confirmed bySEMimages...............................
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